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Cialis (generic name: tadalafil) and Kamagra Gold 100 mg (generic name: sildenafil) are both medications used to treat erectile dysfunction (ED), but they have different mechanisms of action despite belonging to the same class of drugs, called phosphodiesterase type 5 (PDE5) inhibitors. Here are the key distinctions in their mechanisms of action:

Active Ingredient:

Cialis: The active ingredient in Cialis is tadalafil.
Kamagra Gold 100 mg: The active ingredient in Kamagra Gold is sildenafil.
Duration of Action:

Cialis: It is known for its long duration of action, which can last up to 36 hours. This has earned it the nickname "the weekend pill."
Kamagra Gold 100 mg: Its duration of action is typically around 4-6 hours.
Time to Onset of Action:

Cialis: It usually starts working within 30 minutes to 1 hour after administration.
Kamagra Gold 100 mg: It typically starts working within 30 minutes to 1 hour after administration.
Mechanism of Action:

Both drugs work by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. Inhibition of PDE5 leads to increased levels of cGMP, which in turn causes relaxation of smooth muscle cells in the blood vessels of the penis, allowing for increased blood flow and thus an erection.
However, tadalafil (Cialis) has a longer half-life compared to sildenafil (Kamagra Gold). This longer half-life contributes to the longer duration of action seen with Cialis.
Dosage Frequency:

Cialis: It is typically taken once daily at a lower dose for the treatment of both ED and benign prostatic hyperplasia (BPH).
Kamagra Gold 100 mg: It is usually taken on an as-needed basis, shortly before anticipated sexual activity.
Food Interaction:

Cialis: Its absorption is not significantly affected by food intake.
Kamagra Gold 100 mg: Its absorption may be delayed when taken with a high-fat meal.
It's essential to note that while both medications are effective in treating erectile dysfunction, individuals may respond differently to each drug, and the choice between them may depend on factors such as the individual's medical history, preferences, and specific needs. It's always best to consult a healthcare professional before starting any new medication.